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The principal cytochrome P450 isoenzyme concerned seems to be CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Approximately eighty five% of the oral dose appears during the urine inside 24 hrs of administration, most since the glucuronide conjugate, with tiny amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity facts.Res

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